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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A study compared treatment with cinacalcet versus treatment with placebo in subjects with known hyperparathyroidism. The primary outcome of the study was the proportion of study subjects with a mean intact parathyroid hormone level < 250 pg/mL. Among the cinacalcet group (n = 371), 43% of subjects achieved the primary outcome; among the placebo group (n =
370), 5% achieved the primary outcome (p<0.05).
Which of the following is the number needed to treat (NNT)?

A) 14
B) 8
C) 1
D) 3

2. The results of a drug-use evaluation study by the P & T Committee reveal that 15 prescribers are using an antibiotic inappropriately. Which of the following is the most effective strategy for improving the drug therapy?

A) Meeting individually with the prescribers to review the results of the study and review educational material
B) Sending the prescriber's a letter with the results of the study and educational material
C) Including the results of the study and educational material in a newsletter distributed to the medical staff
D) Meeting in a seminar with the prescribers to review the results of the study

3. A pharmacotherapy specialist has been asked to provide information on the incidence of a particular side effect for a drug that has now been on the U.S. market for 5 years. The only information available comes from the FDA's MedWatch program. The apparent incidence of a given adverse effect, as determined from the MedWatch database, is likely to be which of the following?

A) Reliable because healthcare institutions such as hospitals are mandated to report all adverse drug events to the FDA
B) Unreliable because reporting healthcare providers usually fail to establish a temporal relationship
C) Unreliable because the voluntary nature of reporting makes numerator data questionable
D) Reliable because the data are accumulated in cooperation with the pharmaceutical industry

4. An 18-year-old patient presents with abrasions on the hands, knees, and shoulder from a recent bicycle accident. Gram-staining of surgical incision and drainage specimens reveals Gram positive cocci in chains. The patient has necrotizing fasciitis and develops bronchospasms after being given penicillin. Which intravenous antibiotic would be best to use in place of penicillin?

A) Sulfamethoxazole/trimethoprim
B) Clindamycin
C) Ciprofloxacin
D) Ceftriaxone

5. A pharmacotherapy specialist is contemplating Writing a case report on a suspected penicillin induced neutropenia in a patient who received intravenous penicillin G for treatment of infective endocarditis. The specialist has established a temporal relationship between the period of medication administration and the onset of neutropenia, and has excluded other potential causes of the adverse effect.
Which of the following is the most appropriate next step in composing the case report?

A) Perform a comprehensive literature search to identify existing literature describing neutropenia in penicillin-treated patients.
B) Collect all pertinent patient information, including past medical history, laboratory data, medication history, and consent.
C) Describe the incidence, severity, and outcome of penicillin-induced neutropenia for the introduction section of the report.
D) Generate ideas and wording for the patient case summary portion of the report.

Solutions: